Celox™ Haemostatic Agents

Celox™ blood clotting granules are actually very high surface area flakes. When they come in contact with blood, Celox™ swells, gels, and sticks together to make a gel like clot, without generating any heat. Celox™ does not set off the normal clotting cascade, it only clots the blood it comes directly into contact with.

This mode of action has a number of major benefits:

  • Quickly clots hypothermic blood.
  • Works on blood thinners.
  • Works on blood with anti-platelet drugs.
  • No heat generated.
  • Leftover material is naturally absorbed by the body.

Simple to Use

The Celox granules mould to the shape of the wound to get firm pressure on to the source of the bleeding even in complex shaped injuries.

Use on:

  • Arterial and venous bleeding.
  • Life-threatening bleeding.
  • Complex and deep wounds.

Celox has been shown to:

  • Save lives.
  • Reliably stop arterial bleeding.1
  • Clot hypothermic blood.

Proven safe

Celox™ blood clotting agents are made with chitosan, a natural polysaccharide.

Chitosan, when treated in the correct way, has many special properties that make it the ideal choice for use in hemostatic agents, including:

  • Rapidly clots blood
  • It is hypoallergenic
  • Has natural antibacterial properties
  • Biodegradable and non-toxic

Chitosan has a known metabolic pathway. That means any left in your body is broken down by normal enzymes and converted into materials normally present in the body. This is unlike other hemostats that can leave mineral residuals in the body 4,5.

Chitosan is digested by lysozyme, a human enzyme which is present is tears, saliva and mucus. It breaks down to give glucosamine a sugar already present in the body and helps lubricate joints6.

The chitosan in Celox is a specific high quality grade selected for medical use from a shellfish source and the product has been through extensive safety testing to the most stringent class of European Medical Device regulations. As part of this work the chitosan has been tested on human subjects with confirmed fish or shrimp hypersensitivity and none of the subjects showed any skin reaction to the chitosan3.

Saves lives fast

Celox haemostat granules quickly forms a plug – in real experience this stops most bleeding within one minute (see figure)2. For major arterial haemorrhage, maintain pressure for 3-5 minutes to ensure haemorrhage is controlled.

Tom Connelly, a tree surgeon from Cambridgeshire, cut through at least a third of his neck and was moments from death after slipping at work in April.

The 21-year-old man was working 25 feet up a tree when he slipped and inflicted deep wounds to his neck and arm with a chainsaw.

The man had blood spurting from the wound as he dangled in mid-air until his colleague managed to lower him to the ground. He was still conscious when paramedics arrived and asked them if he was going to die – but thanks to their expertise he survived. The paramedics managed to staunch the bleeding until the Helimedix team could arrive.

The Magpas team ventilated the patient before packing his injuries with Celox – a specialist gauze used to treat troops in Afghanistan who have suffered major injuries. It was thanks to this ‘miracle’ dressing that the man was stabilised and the bleeding stopped so he could be airlifted to hospital.

Connelly was flown to Addenbrooke’s Hospital in Cambridge where he underwent immediate surgery to repair the blood vessels in his neck.

Fortunately he came through the surgery and was well enough to be transferred to the Royal National Orthopaedic Hospital in London, for nerve repair to his left arm the following day.

Mr Lockier added: “Without those paramedics I am certain he would have died. I can’t praise them enough.”

Read more on the BBC News Website

Celox granules are available in a 35g sachet for major injuries, even if the casualty has more than one bleeding wound.  We also offer the 15 g sachet for situations where every gram of weight saved is vital, still with enough material to treat a life-threatening injury.

Celox Haemostatic Granules – 15g

Celox Rapid Gauze Z-Fold

  1. Kozen B et al, An Alternative Hemostatic Dressing: Comparison of CELOX, HemCon and QuikClot. Academic Emergency Medicine January 2008, Vol 15 No 1.
  2. Celox (chitosan) for haemostasis in massive trauma bleeding: experience in Afghanistan. Pozza M, Millner R. European Journal of Emergency Medicine 18(1):31-33 Feb 2011.
  3. Medtrade data on file.
  4. Moeng SF, Moar JJ. Quikclot masquerading as Glazer shot: a new forensic pathology artefact? Am J Forensic Med Pathol 2012; 33(3): 238-241.
  5. Hoggarth A, Alden M. Evaluation of the use of hemostatic agents and the residual particles left in the wound. Presented at Symposium for Advanced Wound Care, Anaheim, 2010
  6. Int. J. Biol. Macromol., 1992, Vol 14 August
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